Latest update: 29/06/2017

Genes

DNA forms a chain of ± three billion nucleotides (ACGT in various different combinations of three) which together form our genetic code.
You can see this almost endless succession of letters as thousands of pages of text which together form the manual that makes us a human being. This manual contains many thousands of instructions that allow us to function. These are our genes.


Gene expression

During gene expression the introns or nonsense DNA have to be removed. This can only be done if the DNA in a gene is first 'transcribed' into complementary RNA (ribonucleic acid). We call this 'transcription'.

Further processing of the RNA takes place in a process called 'splicing': the introns are cut off so that the various exons in a gene can be assembled and joined together. After this, 'translation' takes place in specialised little factories in the cytoplasm called ribosomes: the RNA is translated into the correct chain of amino acids. After the necessary adaptations, the chain that is thus formed will ultimately create the functional protein.

It is also important to know that (although all our cells contain the same DNA) not all our cells express the same genes. A skin cell behaves differently to a brain cell or an organ cell, so it is controlled by different commands. Different genes may therefore be expressed in each cell type - sometimes in different quantities - or different proteins may interact with each other.

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