Latest update: 29/06/2017

DNA

The human organism is controlled by a code that we call DNA, which is short for DeoxyriboNucleic Acid.
It is present in (almost) all our cells.

DNA is a chain (in humans) of billions of nucleotides (or bases) arranged in a specific sequence. There are only four different bases: adenine (A), cytosine (C), guanine (G) and thymine (T).

These are joined in a constantly changing sequence to a chain of sugars and phosphates, thereby forming a long chain.
They occur in pairs and every base is joined to another base (always the same one):

  • A is always joined to T (and T to A);
  • C always to G (and G to C).

In other words DNA forms a double chain that looks like a rolled-up spiral ladder. Each pair of bases forms a single rung on this ladder. This is the so-called double helix structure of DNA (see the diagram).
The bonded nucleotides - always in groups of three (see genes) - are responsible for making all the amino acids in our body. Amino acids join together to form proteins, and these are in turn needed to build or repair cells and tissues.

In short: the long DNA code controls our whole organism, so those four letters form the basis for all human life.

Nuclear DNA

Virtually all the cells in our body contain genetic material, with the exception of red blood cells and platelets. These have no nucleus and consequently no DNA. Otherwise every cell in the body is made up of a cell wall (cell membrane), cell fluid (cytoplasm) and a nucleus.

DNA as we have described it above is actually nuclear DNA: DNA in the nucleus. In resting cells this looks like an unraveled tangle but it becomes arranged into a more compact structure during cell division. Then the DNA organises itself into smaller, well-defined sections and can be visualised as the 23 pairs of chromosomes that we call our 'karyotype'.

Nuclear DNA is made up of genetic material from your father and mother, and the nucleus therefore contains pairs of chromosomes: you have two copies of each chromosome, one from each parent. Distributed between these 46 chromosomes we find more than 20,000 pairs of genes. Figures for the exact number of genes that a person has are still very uncertain.

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